Sodium Hydroxide → Benzyl 4-(piperidin-4-yl)piperazine-1-carboxylate

Participants

Reaction Steps

To benzyl 4-(1-t-butoxycarbonylpiperidin-4-yl)piperazine 1-carboxylate (2.31 g) was added trifluoroacetic acid (10 ml) while cooling in an ice bath, followed by stirring at room temperature for 3 hr. The reaction mixture was poured into ice water, and a 5N aqueous solution of sodium hydroxide (26 ml) was added thereto. This was extracted with ethyl acetate:tetrahydrofuran=1:1. The organic layer was washed with brine, and dried over anhydrous sodium sulfate. The solvent was removed to provide the crude product of the titled compound as a pale yellow oil (1.93 g).

Provenance & Evidence