2-(4-Fluoro-2-nitrophenyl)acetic acid → 6-fluoro-2,3-dihydro-1H-indol-2-one

Participants

Reaction Steps

With addition of 20 g of palladium on activated carbon (10%), 119 g of 4-fluoro-2-nitrophenylacetic acid (starting material III) are hydrogenated in 600 ml of acetic acid under a hydrogen pressure of 50 psi. The catalyst is filtered off with suction and the solvent is distilled off. The crude product is triturated with 500 ml of petroleum ether, filtered off with suction, washed with water and dried.

Provenance & Evidence