Acetic Anhydride → 1-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

HRID 2265810Notes

Reaction equation

HRID 2265810 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([F:1])[CH:10]=2)[CH2:6][C:7]1=[O:11])(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 37310136-fluoro-2,3-dihydro-1H-indol-2-one2×

Product 1

HCID 581603571-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

Procedure

At 130° C., 82.5 g of 6-fluoro-2-indolinone (starting material IV) are stirred in 180 ml acetic anhydride for 3 hours. After cooling to room temperature, the precipitate is filtered off with suction, washed with 100 ml of petroleum ether and dried.

Workup

  1. filtrationthe precipitate is filtered off with suction
  2. washwashed with 100 ml of petroleum ether
  3. customdried

Sources & evidence

ORD record
ord-c80742ba97624b61b4d7cd8dcba4c722
Source dataset
uspto-grants-2010_12
Patent number
US07858616B2

Reaction notes

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