Triethylamine → HCID 11964747, compound

Participants

Reaction Steps

To a solution of 4-hydroxymethyl-3,4-dihydro-2H-benzo[b]thiepin-5-one (256 mg, 1.23 mmol) in 15 ml of tetrahydrofuran were added, at room temperature, triethylamine (0.19 ml, 1.4 mmol) and α,α,α-trifluoro-m-tolyl isocyanate (345 μl, 2.46 mmol). The mixture was stirred at room temperature for 2 hours, concentrated and purified by column chromatography on silica gel (eluent: 1:2 tert-butyl methyl ether/cyclohexane). The product was obtained in a yield of 180 mg (37%).

Provenance & Evidence