Triethylamine → HCID 11964752, compound

Participants

Reaction Steps

To a solution of 4-hydroxymethyl-3,4-dihydro-2H-benzo[b]thiepin-5-one (300 mg, 1.44 mmol) in 7 ml of tetrahydrofuran were added, at room temperature, triethylamine (0.22 ml, 1.6 mmol) and p-toluenesulfonyl isocyanate (312 mg, 1.586 mmol). The mixture was stirred at room temperature for 1.5 hours, concentrated and purified by column chromatography on silica gel (eluent: 1:9 tert.butyl methyl ether/dichloromethane). The product was obtained in a yield of 250 mg (43%).

Provenance & Evidence