Piperidin-3-ylmethanol → HCID 178515203, compound

HRID 2265841Notes

Reaction equation

HRID 2265841 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16](N5CCNCC5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:27][CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][NH:31][CH2:30]1>>[OH:27][CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][N:31]([C:16]2[CH:15]=[CH:14][C:13]3[NH:12][CH:11]=[C:10]4[C:25](=[O:26])[N:7]([C:1]5[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=5)[N:8]=[C:9]4[C:18]=3[N:17]=2)[CH2:30]1

Participants

3

Reactant 2

HCID 107308Piperidin-3-ylmethanolHCID 178515211HCID 178515211, compound

Product 1

HCID 178515203HCID 178515203, compound

Procedure

The title compound was prepared following the procedure described for 6a using 3-hydroxymethylpiperidine instead of piperazine. 1H-NMR (DMSO-d6) δ (ppm): 1.75 (4H, brm), 2.87 (1H, dd, J=12.91, 9.89 Hz), 3.05 (1H, m), 3.13 (1H, d, J=5.22 Hz), 3.54 (2H, brm), 3.88 (2H, brd, J=2.91 Hz), 7.14 (1H, dt, J=7.42, 1.10 Hz), 7.19 (1H, d, J=9.34 Hz), 7.42 (2H, ddd, J=7.41, 2.20, 1.92 Hz), 7.79 (1H, d, J=9.34 Hz), 8.21 (2H, ddd, J=7.69, 1.92, 1.10 Hz), 8.52 (1H, s). m/z 361.4 (MH+).

Sources & evidence

ORD record
ord-77bb63d34eaa4bd9929d0443abbcb186
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

Loading…