Piperazin-2-one → HCID 178516703, compound

HRID 2265842Notes

Reaction equation

HRID 2265842 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16]([N:19]5[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:27]=C1CNCCN1>>[O:27]=[C:23]1[NH:22][CH2:21][CH2:20][N:19]([C:16]2[CH:15]=[CH:14][C:13]3[NH:12][CH:11]=[C:10]4[C:25](=[O:26])[N:7]([C:1]5[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=5)[N:8]=[C:9]4[C:18]=3[N:17]=2)[CH2:24]1

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 178515211HCID 178515211, compound

Product 1

HCID 178516703HCID 178516703, compound

Procedure

The title compound was prepared following the procedure described for 6a using 2-oxopiperazine instead of piperazine. 1H-NMR (DMSO-d6) δ (ppm): 3.08 (2H, m), 3.90 (2H, dd, J=5.67, 4.94), 4.19 (2H, s), 7.15 (1H, dd, J=7.42, 1.09 Hz), 7.20 (1H, d, J=9.34 Hz), 7.40 (2H, dd, J=8.51, 7.42 Hz), 7.85 (1H, d, J=9.06 Hz), 8.16 (1H, br), 8.22 (1H, dd, J=7.70, 1.09 Hz), 8.57 (1H, s). m/z 361.4 (MH+).

Sources & evidence

ORD record
ord-fbf93c05a5cd499da7ea26852a385a42
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

Loading…