HCID 59597487, compound → HCID 59597488, compound

HRID 2265854Notes

Reaction equation

HRID 2265854 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[Cl:16])=[N:13][C:12](F)=[CH:11][CH:10]=2)=[O:5])[CH3:2].C(OC(C1C=NC2C(C=1O)=CN=C([Cl:34])C=2)=O)C>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:10]([C:15]=1[Cl:16])=[CH:11][CH:12]=[N:13][C:14]=2[Cl:34])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 59597487HCID 59597487, compoundHCID 178469567HCID 178469567, compound

Product 1

HCID 59597488HCID 59597488, compound

Procedure

The title compound was prepared following the procedure described for 4a using 8-chloro-4-hydroxy-[1,7]naphthyridine-3-carboxylic acid ethyl ester (11). 1H-NMR (CDCl3) δ (ppm): 1.47 (3H, t, J=7.14 Hz), 4.53 (2H, q, J=7.14 Hz), 8.13 (1H, d, J=5.8 Hz), 8.55 (1H, d, J=5.8 Hz), 9.35 (1H, s). m/z 271.0 (MH+).

Sources & evidence

ORD record
ord-a2b1eeb20e9f4479904565e9a8fffe07
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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