HCID 178515199, compound → HCID 178515234, compound

HRID 2265856Notes

Reaction equation

HRID 2265856 reaction equation
[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[CH:14]=[CH:15][C:16](N5CCNCC5)=[N:17][C:18]=4[C:9]3=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC1C=C[C:35]2[NH:34][CH:33]=[C:32]3C(=O)N(C4C=CC=CC=4)N=C3[C:30]=2[N:29]=1>>[C:1]1([N:7]2[C:25](=[O:26])[C:10]3=[CH:11][NH:12][C:13]4[C:18]([N:29]5[CH2:30][CH2:35][NH:34][CH2:33][CH2:32]5)=[N:17][CH:16]=[CH:15][C:14]=4[C:9]3=[N:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 178515199HCID 178515199, compoundHCID 178515211HCID 178515211, compound

Product 1

HCID 178515234HCID 178515234, compound

Procedure

The title compound was prepared following the procedure described in Step 4 for synthesis for 6a using 16 instead of 5a. 1H-NMR (DMSO-d6) δ (ppm): 3.2 (4H, brm), 3.48 (4H, brm), 7.13 (1H, m), 7.46 (2H, m), 7.78 (1H, d, J=5.2 Hz), 8.18 (2H, d, J=7.7 Hz), 8.30 (1H, d, J=5.2 Hz), 8.50 (1H, s). m/z 347.4 (MH+).

Sources & evidence

ORD record
ord-0dd801e46df848debd0123758d751fad
Source dataset
uspto-grants-2010_12
Patent number
US07858614B2

Reaction notes

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