Aluminium lithium hydride → HCID 21956361, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-methyl-6-nitro-3-[(trityloxy)methyl]-2H-indazole (0.50 g, 1.11 mmol) in anhydrous THF under nitrogen atmosphere at 0° C. was added LiAlH4 (2.7 ml, 1.0 M in THF, 2.7 mmol). The solution was stirred at 0° C. for ˜3 h then cooled to −78° C. and quenched with wet THF. The resulting mixture was conc. in vacuo then repeatedly triturated with CH3CN. The combined CH3CN was conc. in vacuo to give crude 2-methyl-3-[(trityloxy)methyl]-2H-indazol-6-amine (0.593 g, 108% TY). MS (ES+, m/z) 420 (M+H).

Provenance & Evidence