反应详情

温度

0 °C

16.1 g (0.138 mol) of chlorosulfonic acid are slowly added dropwise to a solution of 13.05 g of 4-fluorophenoxybenzene (0.069 mol) cooled to 0° C. After the addition is complete, the mixture is stirred at room temperature for a further 4 hours. For work up, 50 ml of dichloromethane are added, and the mixture is washed once with H2O. The aqueous phase is separated off and extracted twice more with 50 ml of dichloromethane each time. The combined organic phases are dried with MgSO4 and concentrated, resulting in the title compound as a colorless solid. Yield: 11.03 g; 60%.

1. additionAfter the addition
2. washthe mixture is washed once with H2O
3. customThe aqueous phase is separated off
4. extractionextracted twice more with 50 ml of dichloromethane each time
5. dry with materialThe combined organic phases are dried with MgSO4
6. concentrationconcentrated