Potassium Hydroxide → HCID 66879173, compound

Participants

Reaction Steps

0.25 g (0.38 mmol) of ethyl 8-bromo-2-[4-(4-fluorophenoxy)benzenesulfonyl]-5-(2-piperidin-1-ylethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate are mixed with 2 ml of 2 N KOH in 7 ml of methanol and stirred at room temperature. After two hours, a further 2 ml of 2 N KOH are added, and stirring is continued for one hour. For workup, the methanol is removed in a rotary evaporator and the aqueous residue is adjusted to a pH of 6-7 with 2 N HCl. The precipitate is filtered off with suction and dried to afford 0.13 g of the desired carboxylic acid.

Provenance & Evidence