HCID 67229718, compound → HCID 178453914, compound

HRID 2265915Notes

Reaction equation

HRID 2265915 reaction equation
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][N:9]=[C:8]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[C:7]=2[CH:17]=1.[C:18]([O:22][C:23](=[O:34])[NH:24][C@H:25]1[CH2:30][CH2:29][C@H:28]([CH2:31][CH:32]=O)[CH2:27][CH2:26]1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23](=[O:34])[NH:24][C@H:25]1[CH2:26][CH2:27][C@H:28]([CH2:31][CH2:32][N:14]2[CH2:13][CH2:12][N:11]([C:8]3[C:7]4[CH:17]=[C:3]([F:2])[CH:4]=[CH:5][C:6]=4[O:10][N:9]=3)[CH2:16][CH2:15]2)[CH2:29][CH2:30]1)([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 67229718HCID 67229718, compoundHCID 178453924HCID 178453924, compound2×

Product 1

HCID 178453914HCID 178453914, compound

Procedure

The title compound, MS: m/e=447.1 (M+H+), can be prepared in accordance with the general method of example 1, step 1 from 5-fluoro-3-piperazin-1-yl-benzo[d]isoxazole hydrochloride and trans-[4-(2-oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (intermediate A).

Sources & evidence

ORD record
ord-e08df680280d413e89153d063439d546
Source dataset
uspto-grants-2010_12
Patent number
US07858630B2

Reaction notes

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