Water → Risedronate Sodium

HRID 2265925Notes

Reaction equation

HRID 2265925 reaction equation
[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:14]([OH:17])([OH:16])=[O:15])([P:10]([OH:13])([OH:12])=[O:11])[OH:9])[CH:2]=1.O.[OH-].[Na+:20]>C(O)(C)(C)C>[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:10]([O-:12])([OH:13])=[O:11])([P:14]([OH:17])([OH:16])=[O:15])[OH:9])[CH:2]=1.[Na+:20]

Participants

5

Reactant 3

HCID 962WaterHCID 5245RisedronateHCID 14798Sodium Hydroxide

Product 1

HCID 4194514Risedronate Sodium

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

20.0 g of risedronic acid, 70 ml of deionized water and 100 ml of ter-butanol are charged into a 1-liter reactor, equipped with mechanical stirrer and thermometer. The suspension, under stirring, is added with 70.7 ml of 1M NaOH. The admixture is kept under stirring for 10′, up to complete dissolution of the undissolved solids. The solution, whose pH is 4.60, is filtered on a paper filter and put into Lioguard chambers. The chambers are introduced into a lyophilizer and processed according to example 1. At the end 19.8 g of lyophilized amorphous sodium risedronate are thus obtained (yields 92.6%).

Workup

  1. customequipped with mechanical stirrer
  2. stirringunder stirring for 10′, up
  3. dissolutiondissolution of the undissolved solids
  4. filtrationThe solution, whose pH is 4.60, is filtered on a paper
  5. filtrationfilter
  6. additionThe chambers are introduced into a lyophilizer

Sources & evidence

ORD record
ord-17d62b38c4654dcf801fb8a0929a069b
Source dataset
uspto-grants-2010_12
Patent number
US07858634B2

Reaction notes

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