Potassium Hydroxide → HCID 22223215, compound
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7](=[CH2:10])[C:8]#[N:9].[OH-:11].[K+]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7](=[CH2:10])[C:8]([NH2:9])=[O:11]Participants
3
Procedure
The Scheme 18 shows a proposed process for synthesizing pyridinyl acrylamide (76). Diketone (72) is reacted with compound (35) to yield pyridinyl ketone compound (73), which is transformed to the pyridinyl acrylonitrile compound (74) by reacting with cyanomethylphosphonic acid diethyl ester and NaH. 3-(2-Alkyl-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (75) obtained by hydrolyzing the pyridinyl acrylonitrile compound (74) with KOH is reacted with the amine compound (1) to yield pyridinyl acrylamide (76).
Sources & evidence
- ORD record
- ord-e8f9bc44404546928785fb976362e87f
- Source dataset
- uspto-grants-2010_12
- Patent number
- US07858621B2
Reaction notes
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