HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-pyrrolidone → HCID 68784808, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Reactant | HCID 68779403 | HCID 68779403 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68784808 | HCID 68784808 | 63% |
Reaction Steps
3-fluoro-4-methanesulfonylaminobenzylamine hydrochloride (17.8 mg, 0.052 mmol) was reacted with 3-(6-tert-butyl-2-methoxy-pyridin-3-yl)-acrylic acid (12 mg) DMTMM (1.1 eq, 16 mg) and NMP (1.2 eq, 90 μl) in THF to give the title compound (14 mg, 61.8%) after purification by column chromatography (Hex EtOAc=3/2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-58bffc6f71084aee872dea81fc754899 |
| Source note | uspto-grants-2010_12 |