反应详情

A suspension of N-(3-fluoro-4-methanesulfonylamino-5-methyl-benzyl)-3-(2-morpholin-4-yl-6-trifluoromethyl-pyridin-3-yl)-acrylamide (32 mg, 0.069 mmol) and 10% Pd/C (3 mg) in MeOH was reacted under hydrogen of 40 psi pressure. The reaction mixture was filtered through celite and then concentrated under reduced pressure to give N-(3-fluoro-4-methanesulfonylamino-5-methyl-benzyl)-3-(2-morpholin-4-yl-6-trifluoromethyl-pyridin-3-yl)-propionamide (22 mg, 69%).

1. customwas reacted under hydrogen of 40 psi pressure
2. filtrationThe reaction mixture was filtered through celite
3. concentrationconcentrated under reduced pressure