HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 59598167, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride | HCID 2734059 | — |
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Reactant | HCID 86625520 | HCID 86625520 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59598167 | HCID 59598167 | 65.5% |
Reaction Steps
3-Fluoro-4-methanesulfonylaminobenzylamine hydrochloride (72 mg, 0.25 mmol) was reacted with (2-bromo-6-tert-butyl-pyridin-3-yloxy)-acetic acid (64 mg), DMTMM (1.2 eq, 83 mg) and NEt3 (2.5 eq, 90 μl) in THF to give the title compound (71 mg, 58.2%) after purification by column chromatography (Hex/EtOAc=1/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-6d3d1c5d4b8643cdaa8096f3f462c4b8 |
| Source note | uspto-grants-2010_12 |