HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 59598286, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Reactant | HCID 86625521 | HCID 86625521 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59598286 | HCID 59598286 | 28.2% |
Reaction Steps
3-Fluoro-4-methanesulfonylaminobenzylamine hydrochloride (21 mg, 0.08 mmol) was reacted with (6-tert-butyl-2-chloro-pyridin-3-yloxy)-acetic acid (1.0 eq, 20 mg) DMTMM (1.2 eq, 27 mg) and NMM (1.5 eq, 14 μl) in THF to give the title compound (10 mg, 28.2%) after purification by column chromatography (Hex/EtOAc=1/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-6bfa25a4e2f84781b0917b61eb30a530 |
| Source note | uspto-grants-2010_12 |