HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 59598175, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Reactant | HCID 68785299 | HCID 68785299 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59598175 | HCID 59598175 | 30.6% |
Reaction Steps
3-Fluoro-4-methanesulfonylaminobenzylamine hydrochloride (192 mg, 0.751 mmol) was reacted with (6-tert-butyl-5-chloro-pyridin-3-yloxy)-acetic acid (183 mg) DMTMM (1.1 eq, 229 mg) and NMM (1.2 eq, 100 μl) in THF to give the title compound (102 mg, 30.6%) after purification by column chromatography (Hex/EtOAc=1/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-0bc1eb84591c4591a2c90088c62de12f |
| Source note | uspto-grants-2010_12 |