HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[4-(aminomethyl)-2,6-difluorophenyl]methanesulfonamide hydrochloride → 3-(6-tert-Butyl-pyridin-3-yl)-N-(3,5-difluoro-4-methane sulfonylamino-benzyl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[4-(aminomethyl)-2,6-difluorophenyl]methanesulfonamide hydrochloride | HCID 21097523 | — |
| Reactant | 3-(6-Tert-butyl-pyridin-3-yl)-acrylic acid | HCID 53416025 | — |
| Product | 3-(6-tert-Butyl-pyridin-3-yl)-N-(3,5-difluoro-4-methane sulfonylamino-benzyl)-acrylamide | HCID 68780251 | 79% |
Reaction Steps
N-(4-Aminomethyl-2,6-difluoro-phenyl)-methanesulfonamide HCl salt (50 mg, 0.18 mmol) was reacted with 3-(6-tert-butyl-pyridin-3-yl)-acrylic acid (37 mg) to give the title compound (60 mg, 79%) after purification by column chromatography (Hex/EtOAc=1/2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-ed4080ac3427445ea98c44ba86cf48f7 |
| Source note | uspto-grants-2010_12 |