Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid → 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid | HCID 72335632 | — |
| 반응물 | 3-Ethynyl-5-fluoro-4-methansulfonylaminobenzylamine hydrochloride | HCID 86625519 | — |
| 생성물 | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide | HCID 74382385 | 90% |
반응 단계
N-(4-Aminomethyl-2-ethynyl-6-fluoro-phenyl)-methanesulfonamide HCl salt (228 mg, 0.795 mmol) was reacted with 3-(2-chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (200 mg, 0.795 mmol) to give the title compound (340 mg, 90%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07858621B2 |
| 출처 데이터셋 | uspto-grants-2010_12 |
| ORD ID | ord-b104e79672b449e2a58db342b54ae101 |
| 출처 메모 | uspto-grants-2010_12 |