Hydrochloric Acid → HCID 68781732, compound

Participants

Reaction Steps

To a solution of 3-(6-methoxy-4-trifluoromethylpyridin-3-yl)-acrylic acid methyl ester (trans isomer, 59 mg, 0.23 mmol) in THF (2 mL) was added 1 N LiOH (2 mL). The mixture was stirred at room temperature for 2 hours, acidified to pH 5 with 3 N HCl, and extracted with EtOAc. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to yield 3-(6-methoxy-4-trifluoromethylpyridin-3-yl)acrylic acid (50 mg, 89.6%) as a solid.

Provenance & Evidence