HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride → 3-(2-chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-fluoro-4-methanesulfonylamino-benzyl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Reactant | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid | HCID 72335632 | — |
| Product | 3-(2-chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-fluoro-4-methanesulfonylamino-benzyl)-acrylamide | HCID 72335664 | 98% |
Reaction Steps
N-(4-Aminomethyl-2-fluoro-phenyl)-methanesulfonamide HCl salt (467 mg, 1.84 mmol) was reacted with 3-(2-chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (420 mg, 1.67 mmol) to give the title compound (737 mg, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-3b56b478537f4b6eb1c6e8fa08386e03 |
| Source note | uspto-grants-2010_12 |