HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride → HCID 68783038, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Reactant | HCID 68782587 | HCID 68782587 | — |
| Product | HCID 68783038 | HCID 68783038 | 70.1% |
Reaction Steps
N-(4-Aminomethyl-2-fluoro-phenyl)-methanesulfonamide HCl salt (57 mg, 0.22 mmol) was reacted with 3-(2-morpholin-4-yl-pyridin-3-yl)-acrylic acid (52 mg, 1.0 eq) to give N-(5-fluoro-4-methanesulfonylamino-benzyl)-3-(2-morpholin-4-yl-pyridin-3-yl)-acrylamide (67 mg, 69.5%) after purification by column chromatography (Hex/EtOAc=1/7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-c9a9120c547c48fd9f1d1fc9a102aa0a |
| Source note | uspto-grants-2010_12 |