HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride → HCID 72335638, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Reactant | HCID 86625528 | HCID 86625528 | — |
| Product | HCID 72335638 | HCID 72335638 | 68.1% |
Reaction Steps
N-(4-Aminomethyl-2-fluoro-phenyl)-methanesulfonamide HCl salt (56 mg, 0.22 mmol) was reacted with 3-(6-chloro-4-trifluoromethyl-pyridin-3-yl)-acrylic acid (54 mg, 1.0 eq) to give 3-(6-chloro-4-trifluoromethyl-pyridin-3-yl)-N-(5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (66 mg, 65.7%) after purification by column chromatography (Hex EtOAc=3/2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-d6742427609d4ff68303c32b3b6eda4e |
| Source note | uspto-grants-2010_12 |