HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride → HCID 72335638, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[4-(aminomethyl)-2-fluorophenyl]methanesulfonamide hydrochloride | HCID 21097525 | — |
| Reactant | HCID 86625528 | HCID 86625528 | — |
| Product | HCID 72335638 | HCID 72335638 | 52.3% |
Reaction Steps
N-(4-Aminomethyl-2-fluoro-phenyl)-methanesulfonamide HCl salt (59 mg, 0.23 mmol) was reacted with 3-(6-chloro-4-trifluoromethyl-pyridin-3-yl)-acrylic acid (50 mg, 1.0 eq) to give 3-(6-chloro-4-trifluoromethyl-pyridin-3-yl)-N-(3-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (47 mg, 49.0%) after purification by column chromatography (Hex/EtOAc=4/5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-93b019ce9b244a5dac7d2c4df62c3b75 |
| Source note | uspto-grants-2010_12 |