Ethanolamine → N-(3-Fluoro-4-methanesulfonylamino-benzyl)-3-[2-(2-hydroxy-ethylamino)-6-trifluoromethyl-pyridin-3-yl]-acrylamide

HRID 2265980Notes

Reaction equation

HRID 2265980 reaction equation
Cl[C:2]1[C:7]([CH:8]=[CH:9][C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([NH:20][S:21]([CH3:24])(=[O:23])=[O:22])=[C:16]([F:25])[CH:15]=2)=[O:11])=[CH:6][CH:5]=[C:4]([C:26]([F:29])([F:28])[F:27])[N:3]=1.[NH2:30][CH2:31][CH2:32][OH:33]>>[F:25][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][C:17]=1[NH:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH2:13][NH:12][C:10](=[O:11])[CH:9]=[CH:8][C:7]1[C:2]([NH:30][CH2:31][CH2:32][OH:33])=[N:3][C:4]([C:26]([F:29])([F:28])[F:27])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 723356643-(2-chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-fluoro-4-methanesulfonylamino-benzyl)-acrylamide

Product 1

HCID 68780459N-(3-Fluoro-4-methanesulfonylamino-benzyl)-3-[2-(2-hydroxy-ethylamino)-6-trifluoromethyl-pyridin-3-yl]-acrylamideYield 24%

Procedure

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-fluoro-4-methane sulfonylamino-benzyl)-acrylamide (40 mg, 0.088 mmol) was reacted with 2-aminoethanol (excess) to give the title compound (10 mg, 24%).

Sources & evidence

ORD record
ord-f959f37a221d4ef0ab8488b4b27f5852
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

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