HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Pyrrolidin-1-yl-6-trifluoromethyl-pyridin-3-yl)-acrylic acid → N-(3-Ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-3-(2-pyrrolidin-1-yl-6-trifluoromethyl-pyridin-3-yl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Pyrrolidin-1-yl-6-trifluoromethyl-pyridin-3-yl)-acrylic acid | HCID 68784003 | — |
| Reactant | 3-Ethynyl-5-fluoro-4-methansulfonylaminobenzylamine hydrochloride | HCID 86625519 | — |
| Product | N-(3-Ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-3-(2-pyrrolidin-1-yl-6-trifluoromethyl-pyridin-3-yl)-acrylamide | HCID 74382535 | 80% |
Reaction Steps
N-(4-Aminomethyl-2-ethynyl-6-fluoro-phenyl)-methanesulfonamide HCl salt (94 mg, 0.327 mmol) was reacted with 3-(2-pyrrolidin-1-yl-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (78 mg, 0.272 mmol) to give the title compound (110 mg, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-9362969b37e247968cc5c3e73b851bf7 |
| Source note | uspto-grants-2010_12 |