反应详情

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (70 mg, 0.057 mmol) was reacted with N-methylpiperazine (30 μl) as in example 46 to give the title compound (13 mg, 15%) after recrystallization with Hex/EtOAc.