3-(2-Butoxy-6-trifluoromethyl-pyridin-3-yl)-acrylic acid → HCID 74382537, compound

HRID 2265986Notes

Reaction equation

HRID 2265986 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([F:10])[C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([C:16]#[CH:17])[CH:5]=1.[CH2:18]([O:22][C:23]1[C:28]([CH:29]=[CH:30][C:31](O)=[O:32])=[CH:27][CH:26]=[C:25]([C:34]([F:37])([F:36])[F:35])[N:24]=1)[CH2:19][CH2:20][CH3:21]>>[CH2:18]([O:22][C:23]1[C:28]([CH:29]=[CH:30][C:31]([NH:2][CH2:3][C:4]2[CH:9]=[C:8]([F:10])[C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])=[C:6]([C:16]#[CH:17])[CH:5]=2)=[O:32])=[CH:27][CH:26]=[C:25]([C:34]([F:37])([F:35])[F:36])[N:24]=1)[CH2:19][CH2:20][CH3:21]

Participants

3

Reactant 2

HCID 687820263-(2-Butoxy-6-trifluoromethyl-pyridin-3-yl)-acrylic acidHCID 866255193-Ethynyl-5-fluoro-4-methansulfonylaminobenzylamine hydrochloride

Product 1

HCID 74382537HCID 74382537, compoundYield 54%

Procedure

N-(4-Aminomethyl-2-ethynyl-6-fluoro-phenyl)-methanesulfonamide HCl salt (25 mg, 0.087 mmol) was reacted with 3-(2-butoxy-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (21 mg, 0.73 mmol) to give the title compound (24 mg, 54%).

Sources & evidence

ORD record
ord-4895bbe6efdf4df381ec535765eaea61
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

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