HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[2-(2-Methoxy-ethoxy)-6-trifluoromethyl-pyridin-3-yl]-acrylic acid → N-(3-Ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-3-[2-(2-methoxy-ethoxy)-6-trifluoromethyl-pyridin-3-yl]-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[2-(2-Methoxy-ethoxy)-6-trifluoromethyl-pyridin-3-yl]-acrylic acid | HCID 68785298 | — |
| Reactant | 3-Ethynyl-5-fluoro-4-methansulfonylaminobenzylamine hydrochloride | HCID 86625519 | — |
| Product | N-(3-Ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-3-[2-(2-methoxy-ethoxy)-6-trifluoromethyl-pyridin-3-yl]-acrylamide | HCID 74382618 | 70.1% |
Reaction Steps
N-(4-Aminomethyl-2-ethynyl-6-fluoro-phenyl)-methanesulfonamide HCl salt (45 mg, 0.156 mmol) was reacted with 3-[2-(2-methoxy-ethoxy)-6-trifluoromethyl-pyridin-3-yl]-acrylic acid (38 mg, 0.13 mmol) to give the title compound (47 mg, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-18c257787a594492946fab0b17b277b5 |
| Source note | uspto-grants-2010_12 |