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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2266000Generated: November 4, 2026

3-(2-Phenoxy-6-trifluoromethyl-pyridin-3-yl)-acrylic acid → N-(3-Ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-3-(2-phenoxy-6-trifluoromethyl-pyridin-3-yl)-acrylamide

https://huagongshe.com/reaction/2266000

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2-Phenoxy-6-trifluoromethyl-pyridin-3-yl)-acrylic acidHCID 68783327—
ReactantHCID 68785944HCID 68785944—
ProductN-(3-Ethynyl-5-fluoro-4-methanesulfonylamino-benzyl)-3-(2-phenoxy-6-trifluoromethyl-pyridin-3-yl)-acrylamideHCID 7438268275%

Reaction Steps

N-(4-Aminomethyl-2-ethenyl-6-fluoro-phenyl)-methanesulfonamide HCl salt (35 mg, 0.13 mmol) was reacted with 3-(2-phenoxy-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (17 mg) to give the title compound (22 mg, 75%) after purification by column chromatography (Hex/EtOAc=1/1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07858621B2
Source datasetuspto-grants-2010_12
ORD IDord-eb5232b02d624dc8b7d96a09c47f7394
Source noteuspto-grants-2010_12