3-Hydroxypyridine → HCID 68783006, compound

Participants

Reaction Steps

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-N-(3-fluoro-4-methanesulfonylamino-benzyl)-acrylamide (48 mg, 0.11 mmol), 3-hydroxypyridine (97 mg) and potassium carbonate (421 mg) were added in 40 ml DMF. The reaction mixture was stirred overnight. The reaction mixture was extracted with ethyl acetate (30 ml×2) and water (30 ml). A combined organic layer was washed with H2O (30 ml×4) and brine (40 ml), dried with MgSO4, and then concentrated in vacuo. The residue was purified with column chromatography (hexane/ethylacetate=1/4) to yield the title compound (46 mg, 82%).

Provenance & Evidence