Thiophene-3-boronic acid → HCID 68780449, compound

HRID 2266009Notes

Reaction equation

HRID 2266009 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[C:8](Cl)=[N:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=1)[CH3:2].[S:19]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20]1>>[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[C:8]([C:21]2[CH:22]=[CH:23][S:19][CH:20]=2)=[N:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 72335620HCID 72335620, compound

Product 1

HCID 68780449HCID 68780449, compoundYield 68%

Procedure

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid ethyl ester (100 mg, 0.357 mmol) was reacted with 3-thienyl boronic acid (2 eq) to give 3-(2-thien-3-yl-6-trifluoromethyl-pyridin-3-yl)-acrylic acid ethyl ester (80 mg, 68%).

Sources & evidence

ORD record
ord-f0656fc7249e4bf1ae6230ed8903c841
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

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