3-Fluorophenylboronic acid → HCID 68782363, compound

HRID 2266010Notes

Reaction equation

HRID 2266010 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[C:8](Cl)=[N:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=1)[CH3:2].[F:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1>>[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[C:8]([C:24]2[CH:23]=[CH:22][CH:21]=[C:20]([F:19])[CH:25]=2)=[N:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 72335620HCID 72335620, compound

Product 1

HCID 68782363HCID 68782363, compoundYield 53%

Procedure

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid ethyl ester (110 mg, 0.393 mmol) was reacted with 3-fluorophenyl boronic acid (2 eq) to give 3-[2-(3-fluoro-phenyl)-6-trifluoromethyl-pyridin-3-yl]-acrylic acid ethyl ester (70 mg, 53%).

Sources & evidence

ORD record
ord-da9dcbb9ea5a4a7bbcb9c672777faec1
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

Loading…