(3-Methoxyphenyl)boronic acid → HCID 68782555, compound

HRID 2266011Notes

Reaction equation

HRID 2266011 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[C:8](Cl)=[N:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=1)[CH3:2].[CH3:19][O:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][CH:26]=1>>[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[C:8]([C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([O:20][CH3:19])[CH:26]=2)=[N:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2734370(3-Methoxyphenyl)boronic acidHCID 72335620HCID 72335620, compound

Product 1

HCID 68782555HCID 68782555, compoundYield 54%

Procedure

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid ethyl ester (103 mg, 0.368 mmol) was reacted with 3-methoxy phenyl boronic acid (2 eq) to give 3-[2-(3-methoxy-phenyl)-6-trifluoromethyl-pyridin-3-yl]-acrylic acid ethyl ester (70 mg, 54%).

Sources & evidence

ORD record
ord-e2922622ce79440ba3838af9c77cb642
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

Loading…