3-Pyridinylboronic acid → HCID 68783193, compound

HRID 2266012Notes

Reaction equation

HRID 2266012 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[C:8](Cl)=[N:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=1)[CH3:2].[N:19]1[CH:24]=[CH:23][CH:22]=[C:21](B(O)O)[CH:20]=1>>[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[C:8]([C:21]2[CH:20]=[N:19][CH:24]=[CH:23][CH:22]=2)=[N:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 72335620HCID 72335620, compound

Product 1

HCID 68783193HCID 68783193, compoundYield 50%

Procedure

3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid ethyl ester (103 mg, 0.368 mmol) was reacted with 3-pyridine boronic acid (2 eq) to give 3-(2-pyridin-3-yl-6-trifluoromethyl-pyridin-3-yl)-acrylic acid ethyl ester (60 mg, 50%).

Sources & evidence

ORD record
ord-8789664bccdc4b39821436e599c99029
Source dataset
uspto-grants-2010_12
Patent number
US07858621B2

Reaction notes

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