Methanol → HCID 86625536, compound

Participants

Reaction Steps

To a suspension of N-methoxy-2-(3-methoxy-prop-1-ynyl)-N-methyl-6-trifluoromethyl-nicotinamide (247 mg, 0.817 mmol) in 5% Pd/C (50 mg) was added CH3OH (6 ml). The mixture was purged three times with hydrogen gas (50 psi) and shaken for 2 hours at room temperature. The reaction mixture was filtered over a pad of Celite and concentrated under reduced pressure. The crude residue was chromatographed to yield the N-methoxy-2-(3-methoxy-propyl)-N-methyl-6-trifluoromethyl-nicotinamide (160 mg, 64%).

Provenance & Evidence