HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanethiol → 3-(2-Isopropylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanethiol | HCID 6364 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid | HCID 72335632 | — |
| Product | 3-(2-Isopropylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid | HCID 68781678 | 36.3% |
Reaction Steps
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (245 mg, 0.974 mmol) was reacted with 2-propanthiol (240 mg, 3.15 mmol) and sodium hydride (143 mg, 3.56 mmol) to afford the title compound (103 mg) after purification by column chromatography (Hex/EtOAc=2.5/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-2e6d13fe45764c3b919ebb84e24e2033 |
| Source note | uspto-grants-2010_12 |