HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propyl mercaptan → 3-(2-Propylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propyl mercaptan | HCID 7848 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid | HCID 72335632 | — |
| Product | 3-(2-Propylthio-6-trifluoromethyl-pyridin-3-yl)-acrylic acid | HCID 68782000 | 40.9% |
Reaction Steps
3-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-acrylic acid (243 mg, 0.966 mmol) was reacted with propanthiol (229 mg, 3.01 mmol) and sodium hydride (145 mg, 3.62 mmol) to afford title compound (115 mg) after purification by column chromatography (Hex EtOAc=2/3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858621B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-e2fdece70e554f36b9f05f95e76a3e8d |
| Source note | uspto-grants-2010_12 |