HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-[5-Chloro-2-(1-fluoro-1-methyl-ethyl)-methoxy-phenoxy]-pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (Diethylamino)sulfur trifluoride | HCID 123472 | — |
| Reactant | 2-Fluoro-1,4-dimethoxybenzene | HCID 145002 | — |
| Reactant | 5-(5-Fluoro-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine | HCID 44573644 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 5-[5-Chloro-2-(1-fluoro-1-methyl-ethyl)-methoxy-phenoxy]-pyrimidine-2,4-diamine | HCID 67053429 | — |
Reaction Steps
Similarly prepared, but starting with 3-fluoro-1,4-dimethoxybenzene, and using hydrogenation with Pd/C in step 4 instead of DAST, was 5-(5-Fluoro-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine (0.778 g, 42%); mp (HCl salt)=239-241° C.; [MH]+=293.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858632B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-0a6614275cd046ffba92e74743130395 |
| Source note | uspto-grants-2010_12 |