HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Isopropyl-4-methoxy-5-trifluoromethyl-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Isopropyl-5-methoxy-2-(toluene-4-sulfonyl)-4-trifluoromethyl-benzene | HCID 67053481 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Isopropyl-4-methoxy-5-trifluoromethyl-phenol | HCID 59598725 | 81% |
Reaction Steps
A solution of 1-Isopropyl-5-methoxy-2-(toluene4-sulfonyl)4-trifluoromethyl-benzene (0.40 g, 1.03 mmol) and NaOH (0.5 g, 12.5 mmol) in MeOH(5ml) and H2O (5ml) was heated at 90° C. for 2 hrs. The cooled reaction mixture was acidified with 3N HCl and extracted into methylene chloride. The combined extracts was dried with Na2SO4, filtered and concentrated to give desired 2-Isopropyl-4-methoxy-5-trifluoromethyl-phenol (0.194 g, 81%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858632B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-c25385c9b68e464289d99a4f509bf1b4 |
| Source note | uspto-grants-2010_12 |