HCID 58207829, compound → HCID 58207872, compound

HRID 2266164Notes

Reaction equation

HRID 2266164 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH2:20][CH2:19][N:18](CC3C=CC=CC=3)[CH2:17][CH2:16]2)[C:12]([O:28][CH3:29])=[CH:11][C:10]=1[C:30]([OH:33])([CH3:32])[CH3:31])C1C=CC=CC=1>CCO>[OH:33][C:30]([C:10]1[CH:11]=[C:12]([O:28][CH3:29])[C:13]([N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)=[CH:14][C:9]=1[OH:8])([CH3:31])[CH3:32]

Participants

3

Reactant 1

HCID 58207829HCID 58207829, compound

Product 1

HCID 58207872HCID 58207872, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-[2-Benzyloxy-4-(4-benzyl-piperazin-1-yl)-5-methoxy-phenyl]-propan-2-ol (2.01 g, 4.5 mmol) 10% Pd/C (0.28 g) in EtOH (60 mL) was hydrogenated at 50 psi at room temperature for 12 hours. The reaction mixture was filtered to remove the catalyst, and the filtrate was concentrated uner reduced pressure to yield 1.1 g (92% ) of 2-(1-Hydroxy-1-methyl-ethyl)-4-methoxy-5-piperazin-1-yl-phenol.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customto remove the catalyst
  3. concentrationthe filtrate was concentrated uner reduced pressure

Sources & evidence

ORD record
ord-7da65828f76646a28331885f800fca8c
Source dataset
uspto-grants-2010_12
Patent number
US07858632B2

Reaction notes

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