反应详情

1-Thiophen-3-yl-butan-1-one (6.7 g. 43 mmol) in 210 mL diethyl ether was cooled to zero degrees C, and 0.6 ml glacial acetic acid was added dropwise, followed by bromine (2.26 ml, 46 mmol) dropwise. The reaction mixture was allowed to warm to room temperature over hours. The reaction mixture was washed the with water, 1 N sodium thiosulfate, brine, and then dried over magnesium sulfate. Solvent was removed under reduced pressure to give an oil which was chromatographed (5% EtOAc/Hexanes) to give 6.1 g 2-Bromo-1-thiophen-3-yl-butan-1-one, 79% , as an oil.

1. washThe reaction mixture was washed the with water, 1 N sodium thiosulfate, brine
2. dry with materialdried over magnesium sulfate
3. customSolvent was removed under reduced pressure
4. customto give an oil which
5. customwas chromatographed (5% EtOAc/Hexanes)