4-Methyl-1-pentyne → HCID 59598503, compound

HRID 2266237Notes

Reaction equation

HRID 2266237 reaction equation
C([C:5]1[O:6][C:7]2[C:13]([C@:14]([C@@H:22]3[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]3)([OH:21])[CH2:15][CH2:16][CH2:17][CH2:18][O:19][CH3:20])=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)C(C)C.[CH3:28][CH:29]([CH3:33])[CH2:30]C#C>>[C:29]([C:5]1[O:6][C:7]2[C:13]([C@:14]([C@@H:22]3[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]3)([OH:21])[CH2:15][CH2:16][CH2:17][CH2:18][O:19][CH3:20])=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)([CH3:33])([CH3:30])[CH3:28]

Participants

3

Reactant 2

HCID 1389484-Methyl-1-pentyneHCID 67192925HCID 67192925, compound

Product 1

HCID 59598503HCID 59598503, compound

Procedure

(S)-1-(2-isobutylbenzofuran-7-yl)-5-methoxy-1-((R)-piperidin-3-yl)pentan-1-ol using 4-methylpentyne in place of 3,3-dimethylbut-1-yne in Step 1.

Sources & evidence

ORD record
ord-e8d415b54136422789cec3edb908cb9b
Source dataset
uspto-grants-2010_12
Patent number
US07858624B2

Reaction notes

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