Methyl N-(triethylammoniosulfonyl)carbamate → HCID 68696606, compound

Participants

Reaction Steps

A mixture of (R)-tert-butyl 2-((R)-1-(6-fluoro-3′-methylbiphenyl-2-yl)-1-hydroxy-5-methoxypentyl)morpholine-4-carboxylate (188 mg, 0.39 mmol) and Burgess' reagent (186 mg, 0.78 mmol) in toluene (3 mL) was heated to reflux under a N2 atmosphere for 2 h, then cooled to rt and diluted with EtOAc, washed with H2O and brine, dried over Na2SO4, filtered and evaporated. The residue was purified by flash chromatography to give (S)-tert-butyl 2-(1-(6-fluoro-3′-methylbiphenyl-2-yl)-5-methoxypent-1-enyl)morpholine-4-carboxylate (133 mg, 73%). MS m/z 470 (M+H)+.

Provenance & Evidence