(Diethylamino)sulfur trifluoride → HCID 178453975, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (t-butoxy)-N-(4-hydroxycyclohexyl)carboxamide (1 equivalent) in CH2Cl2 (1 M) cooled to −78° C. was added dropwise a solution of DAST (1 equivalent) in CH2Cl2 (0.5 M). The mixture was stirred at −78° C. for 4 hours, and then allowed to rise to room temperature. The solution was poured into saturated NaHCO3 and extracted with chloroform, dried, and evaporated. The resulting crude product was purified on silica gel, eluting with ethyl acetate/hexane 5:95.

Provenance & Evidence