Methyl iodide → HCID 57933498, compound

Participants

Reaction Steps

1.0 g 2-Hydroxy-(trifluoromethoxy)benzoic acid were dissolved in 30 ml dimethylformamide. 640 mg iodomethane and 4.70 g cesium carbonate were added and the reaction mixture was stirred at room temperature for three hours. The reaction mixture was diluted by addition of 100 ml ethyl acetate, washed with 30 ml water and brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 590 mg 2-Methoxy-4-trifluoromethoxy-benzoic acid methyl ester.

Provenance & Evidence