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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2266405Generated: November 1, 2026

Iodoethane → HCID 67231612, compound

https://huagongshe.com/reaction/2266405

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodoethaneHCID 6340—
ReactantMethyl 3-hydroxy-5-(trifluoromethyl)thiophene-2-carboxylateHCID 2759855—
SolventDimethylformamideHCID 6228—
SolventCesium carbonateHCID 10796—
ProductHCID 67231612HCID 67231612—

Reaction Steps

The 3-ethoxy-5-trifluoromethyl-thiophene-2-carboxylic acid methyl ester (mp.: 93.6° C.) was prepared from the known adduct 3-hydroxy-5-trifluoromethyl-thiophene-2-carboxylic acid methyl ester (Synthesis 2000, No. 8, 1078-1080) by alkylation with ethyl iodide in the presence of cesium carbonate in DMF as solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07858647B2
Source datasetuspto-grants-2010_12
ORD IDord-0c21385984aa4c88ae9297f48eebacd6
Source noteuspto-grants-2010_12